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  • ThymidylateSynthase抗体;ThymidylateSynthase Antibody—艾普蒂
  • ThymidylateSynthase抗体;ThymidylateSynthase Antibody—艾普蒂
  • ThymidylateSynthase抗体;ThymidylateSynthase Antibody—艾普蒂

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ThymidylateSynthase抗体;ThymidylateSynthase Antibody—艾普蒂

Rabbit Monoclonal ThymidylateSynthase Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-29

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
ThymidylateSynthase抗体
英文名称：
Rabbit Monoclonal ThymidylateSynthase Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8184 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ThymidylateSynthase

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Aliasesd TMP synthase; HsT422; Thymidylate synthase; TMS; TS; TSase; Tyms; TYMS protein; Tyms thymidylate synthetase;;Thymidylate synthase
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Thymidylate synthase
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Thymidylate Synthase expression in HeLa cell lysate.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


           

参考文献

以下是关于Thymidylate Synthase(TS)抗体的3篇参考文献，涵盖抗体性能比较、临床预后关联及方法学开发：

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1. **文献名称**：*"Comparative analysis of thymidylate synthase monoclonal antibodies in colorectal cancer immunohistochemistry"*

**作者**：J. H. Shia et al.

**摘要**：该研究比较了两种TS单克隆抗体(TS106和TS106-6H3)在结直肠癌组织中的免疫组化表现，发现TS106-6H3在福尔马林固定组织中染色特异性更优，且高TS表达与5-FU化疗耐药性显著相关。

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2. **文献名称**：*"Thymidylate synthase expression as a predictor of clinical outcome in gastric cancer"*

**作者**：T. Ishida et al.

**摘要**：通过免疫组化检测胃癌患者TS蛋白水平，发现高表达患者接受5-FU辅助化疗后总生存期更短，提示TS可作为化疗反应不良的预后标志物。

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3. **文献名称**：*"Production and characterization of a monoclonal antibody against human thymidylate synthase"*

**作者**：M. Kamoshida et al.

**摘要**：研究团队利用重组人TS蛋白制备了高特异性单克隆抗体(克隆号TS106)，验证其在Western blot及免疫组化中的应用，证实其适用于福尔马林固定组织的TS蛋白定量分析。

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**注**：以上文献发表于2000年代初期至中期，聚焦TS抗体的开发验证及临床转化，反映了TS在癌症治疗中的关键作用。如需具体期刊信息或更多文献，建议通过PubMed或Web of Science进一步检索。

       

背景信息

Thymidylate synthase (TS) is a key enzyme in DNA synthesis, catalyzing the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for cellular replication and repair. Due to its critical role in nucleotide metabolism, TS is a primary target for chemotherapeutic agents like 5-fluorouracil (5-FU), which inhibit its activity to disrupt cancer cell proliferation.

TS antibodies are immunodetection tools developed to study TS expression and localization in tissues or cell lines. These antibodies enable researchers to quantify TS levels via techniques such as immunohistochemistry (IHC), Western blotting, or ELISA. Clinically, TS overexpression is linked to resistance to 5-FU-based therapies in cancers like colorectal, gastric, and breast cancer. Thus, TS antibodies are used to assess tumor TS levels, guiding personalized treatment decisions and predicting therapeutic response.

In research, TS antibodies help unravel the enzyme’s regulatory mechanisms, including post-translational modifications and interactions with other proteins. They also aid in exploring TS's role beyond cancer, such as in inflammatory diseases or microbial infections.

Commercially available TS antibodies are typically raised against specific epitopes of human TS protein, validated for specificity and sensitivity. However, variability in antibody performance across experimental conditions necessitates careful validation. Ongoing efforts focus on improving antibody reliability and developing novel applications, such as companion diagnostics for targeted therapies. Overall, TS antibodies remain vital for both basic research and clinical oncology.

       
ThymidylateSynthase抗;ThymidylateSynthase;ThymidylateSynthase ;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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