C4抗体;C4 Antibody—艾普蒂 新品

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     Western blot analysis of C4 expression in HepG2 cell lysate.    

  
  

C4 antibody targets complement component 4 (C4), a critical protein in the complement system, an innate immune defense mechanism. C4 exists as two isoforms, C4A and C4B, encoded by highly polymorphic genes in the major histocompatibility complex (MHC) region. It plays a central role in the classical and lectin pathways of complement activation. Upon pathogen recognition, C4 is cleaved into C4a (anaphylatoxin) and C4b, which opsonizes pathogens or forms C3 convertase to amplify immune responses.

C4 antibodies are widely used in research and diagnostics to quantify C4 levels, assess complement activation, or detect genetic deficiencies linked to autoimmune diseases like systemic lupus erythematosus (SLE). Reduced C4 levels, often measured via immunoassays, can indicate complement consumption in autoimmune disorders or infections. Autoantibodies against C4. though rare, have been reported in certain conditions.

Notably, C4 gene copy number variations and polymorphisms influence disease susceptibility. For example, low C4A copies are associated with SLE, while C4B deficits may correlate with infections. C4 antibodies also aid in studying complement’s role in tissue inflammation, neurodegenerative diseases, and transplant rejection. Their applications extend to therapeutic monitoring, as complement inhibitors targeting C4/C4b are explored for treating complement-mediated disorders.