GABABReceptor1抗体;GABABReceptor1 Antibody—艾普蒂 新品

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     Western blot analysis of GABA B Receptor 1 expression in HeLa cell lysate.    

  
  

The GABA_B receptor 1 (GABA_BR1) antibody is a critical tool for studying the GABA_B receptor, a class of metabotropic G protein-coupled receptors (GPCRs) that mediate the inhibitory effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. The GABA_B receptor exists as a heterodimer composed of GABA_BR1 and GABA_BR2 subunits, with GABA_BR1 being essential for ligand binding and GABA_BR2 facilitating signal transduction. This receptor modulates synaptic transmission, neuronal excitability, and plasticity, playing roles in conditions like anxiety, epilepsy, and chronic pain.

Antibodies targeting GABA_BR1 are widely used in neuroscience research to investigate receptor expression, localization, and function in tissues or cell models. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, helping to map receptor distribution in the brain and study its involvement in neurological disorders. Specificity is critical, as GABA_BR1 has splice variants (e.g., GABA_BR1a/R1b) with distinct roles. Many antibodies are raised against epitopes in the extracellular or cytoplasmic domains, validated for cross-reactivity across species like human, mouse, and rat.

Research using GABA_BR1 antibodies has advanced understanding of synaptic regulation and therapeutic targeting, particularly for drugs treating spasticity, addiction, and neuropathic pain. However, challenges remain in distinguishing isoforms and ensuring minimal cross-reactivity with related proteins. Proper validation via knockout controls or peptide blocking is essential for reliable results.