GLUR抗体;GLUR Antibody—艾普蒂 新品

Glutamate receptors (GluRs) are critical neurotransmitter receptors in the central nervous system, mediating excitatory synaptic transmission. They are broadly categorized into ionotropic (iGluRs) and metabotropic (mGluRs) receptors. iGluRs, including NMDA, AMPA, and kainate subtypes, are ligand-gated ion channels essential for synaptic plasticity, learning, and memory. mGluRs are G protein-coupled receptors modulating synaptic activity and neuronal communication. Antibodies targeting GluRs are vital tools in neuroscience research, enabling the localization, quantification, and functional analysis of these receptors in tissues or cultured cells. For example, anti-AMPA receptor antibodies help study their role in long-term potentiation, while anti-NMDA receptor antibodies are used to investigate neurological disorders like schizophrenia or epilepsy. Clinically, autoantibodies against GluRs (e.g., anti-NMDA receptor antibodies) are biomarkers for autoimmune encephalitis, aiding diagnosis and treatment. Researchers also utilize GluR antibodies to explore pathological mechanisms in neurodegenerative diseases, such as Alzheimer’s, where receptor dysregulation is implicated. These antibodies are typically validated via techniques like immunohistochemistry, western blotting, or electrophysiology to ensure specificity and reliability. Their application advances both basic understanding of neural circuits and therapeutic development for neurological and psychiatric conditions.