SPHK1抗体;SPHK1 Antibody—艾普蒂

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     Western blot analysis of SPHK1 expression in Raji cell lysate.    

  
  

The SPHK1 (sphingosine kinase 1) antibody is a research tool designed to detect and study the sphingosine kinase 1 enzyme, a key regulator of sphingolipid metabolism. SPHK1 catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a bioactive lipid mediator involved in diverse cellular processes, including cell proliferation, survival, migration, and immune response modulation. Dysregulation of SPHK1/S1P signaling has been implicated in pathologies such as cancer, inflammation, and metabolic disorders, making SPHK1 a target for therapeutic development.

SPHK1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and activity in tissues or cultured cells. These antibodies help researchers investigate SPHK1's role in disease mechanisms, such as tumor progression (via promoting angiogenesis and metastasis) or inflammatory conditions (by regulating immune cell trafficking). Monoclonal and polyclonal variants are available, often raised in hosts like rabbits or mice, with validation for specificity and cross-reactivity. Recent studies also explore SPHK1's potential as a biomarker or drug target, driving demand for reliable antibodies to support preclinical and diagnostic research.