FTMT抗体;FTMT Antibody—艾普蒂 新品

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     Western blot analysis of FTMT expression in HepG2 cell lysate.    

  
  

**Background of FTMT Antibody**

Ferritin mitochondrial (FTMT) is an iron-storage protein localized primarily in mitochondria, playing a critical role in regulating cellular iron homeostasis and protecting against oxidative stress by sequestering excess iron. Unlike cytoplasmic ferritin, FTMT is encoded by the *FTMT* gene (also called *FTL2*) and is crucial for mitochondrial iron buffering, heme synthesis, and iron-sulfur cluster biogenesis. Dysregulation of FTMT is linked to mitochondrial dysfunction, oxidative damage, and diseases such as neurodegenerative disorders (e.g., Alzheimer's and Parkinson’s) and certain cancers.

FTMT antibodies are immunological tools designed to detect and quantify FTMT expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study FTMT's localization, expression patterns, and interactions under physiological or pathological conditions. These antibodies help elucidate FTMT's role in iron metabolism, its response to oxidative stress, and its involvement in disease mechanisms. Recent studies also explore FTMT as a potential biomarker or therapeutic target, particularly in conditions associated with mitochondrial iron overload or oxidative damage. Validated FTMT antibodies are essential for advancing research into mitochondrial-related pathologies and iron dysregulation.