GPX4抗体;GPX4 Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The glutathione peroxidase 4 (GPX4) antibody is a critical tool in studying the role of GPX4. a selenium-containing antioxidant enzyme essential for cellular redox homeostasis. GPX4 uniquely reduces lipid hydroperoxides within membranes, thereby preventing ferroptosis—a form of regulated cell death driven by iron-dependent lipid peroxidation. This enzyme is pivotal in mitigating oxidative damage, particularly in tissues with high metabolic activity, such as the liver, brain, and kidneys. Dysregulation of GPX4 is linked to pathologies including cancer, neurodegenerative diseases, and ischemia-reperfusion injury.

GPX4 antibodies are widely used in research to detect protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate GPX4's involvement in ferroptosis modulation, its interaction with pathways like the glutathione and mevalonate systems, and its role in therapeutic resistance. For instance, cancer studies exploit GPX4 antibodies to explore tumor survival mechanisms, as GPX4 inhibition can sensitize cells to ferroptosis inducers. Similarly, in neurodegenerative research, these antibodies aid in understanding how GPX4 depletion exacerbates lipid peroxidation in conditions like Alzheimer’s disease.

The development of specific, high-affinity GPX4 antibodies remains vital for advancing mechanistic insights and therapeutic strategies targeting ferroptosis-related diseases.