NF2/Merlin抗体;NF2/Merlin Antibody—艾普蒂 新品

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     Western blot analysis of NF2 / Merlin expression in (1) HeLa cell lysate; (2) PC3 cell lysate.    

  
  

**Background of NF2/Merlin Antibodies**

NF2/Merlin antibodies are essential tools for studying the NF2 tumor suppressor gene and its encoded protein, Merlin. The *NF2* gene, located on chromosome 22q12.2. encodes Merlin (Moesin-Ezrin-Radixin-Like Protein), a cytoskeletal protein critical for regulating cell proliferation, adhesion, and signaling. Merlin functions as a tumor suppressor by integrating extracellular cues with intracellular pathways, such as the Hippo-YAP/TAZ and PI3K/AKT/mTOR pathways, to control tissue homeostasis. Mutations in *NF2* cause neurofibromatosis type 2 (NF2), a hereditary disorder characterized by benign tumors in the nervous system, including schwannomas, meningiomas, and ependymomas.

Antibodies targeting NF2/Merlin are widely used in research to detect protein expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate Merlin’s role in tumor suppression, cytoskeletal organization, and cell membrane stability. Specific antibody clones (e.g., anti-Merlin D1D8. A-19) are validated for specificity and sensitivity across experimental models, including cell lines, animal tissues, and human tumor samples.

Research using NF2/Merlin antibodies has advanced understanding of tumorigenesis mechanisms and potential therapeutic targets, particularly for NF2-related syndromes and sporadic cancers with Merlin dysfunction. Their application also extends to drug development and biomarker studies, highlighting their importance in both basic and translational oncology.