Reptin/RUVBL2抗体;Reptin/RUVBL2 Antibody—艾普蒂 新品

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     Western blot analysis of Reptin / RUVBL2 expression in (1) HeLa cell lysate; (2) NIH/3T3 cell lysate.    

  
  

**Background of Reptin/RUVBL2 Antibody**

Reptin, also known as RUVBL2 (RuvB-like AAA ATPase 2), is a conserved eukaryotic protein belonging to the AAA+ (ATPases Associated with diverse cellular Activities) superfamily. It forms a heterohexameric complex with its paralog RUVBL1. functioning as an ATP-dependent molecular chaperone involved in chromatin remodeling, transcriptional regulation, DNA repair, and cellular signaling. RUVBL2 interacts with diverse protein complexes, including INO80/SWR1 chromatin remodelers, RNA polymerase II, and the TIP60 histone acetyltransferase complex, playing critical roles in cell proliferation, differentiation, and stress responses.

Antibodies targeting Reptin/RUVBL2 are essential tools for studying its expression, localization, and interactions. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in investigations of its mechanistic roles in diseases. Dysregulation of RUVBL2 is linked to cancer progression, neurodegenerative disorders, and immune dysfunctions, making it a potential therapeutic target. These antibodies help validate protein knockdown/overexpression models and assess clinical correlations in tissue samples. Researchers also use them to explore RUVBL2’s ATPase activity, structural dynamics, and partnerships in multi-protein assemblies, advancing understanding of its contributions to genome stability and cellular homeostasis.