Bag3抗体;Bag3 Antibody—艾普蒂

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     Western blot analysis of Bag3 expression in K562 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

**Background of BAG3 Antibody**

BAG3 (Bcl-2-associated athanogene 3) is a member of the BAG protein family, known for regulating apoptosis, autophagy, and cellular stress responses. It acts as a co-chaperone with Hsp70. modulating protein quality control by facilitating the selective degradation of misfolded proteins via autophagy or the ubiquitin-proteasome system. BAG3 is highly expressed in tissues subjected to mechanical stress, such as skeletal muscle, heart, and the central nervous system, where it supports cell survival under stress conditions.

Dysregulation of BAG3 is linked to various diseases. In cancer, elevated BAG3 levels are associated with tumor progression, metastasis, and chemoresistance by inhibiting apoptosis and promoting pro-survival pathways. In neurodegenerative disorders (e.g., Alzheimer’s, Huntington’s), BAG3 aids in clearing toxic protein aggregates, though its dysfunction may exacerbate pathology. Mutations in the *BAG3* gene cause severe myopathies and cardiomyopathies, highlighting its role in maintaining structural integrity in muscle cells.

BAG3 antibodies are essential tools for studying its expression, localization, and interaction partners. They are used in techniques like Western blot, immunohistochemistry, and immunofluorescence to investigate BAG3’s role in disease mechanisms or therapeutic targeting. Clinically, BAG3 antibodies may aid in diagnosing BAG3-related disorders or monitoring treatment efficacy, particularly in cancers or neurodegenerative conditions where BAG3 is a potential biomarker or therapeutic target. Research continues to explore its dual roles in cytoprotection and disease progression, emphasizing its therapeutic potential.