IRAK抗体;IRAK Antibody—艾普蒂

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     Western blot analysis of IRAK expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

**Background of IRAK Antibodies**

Interleukin-1 receptor-associated kinase (IRAK) antibodies are essential tools for studying the IRAK family of proteins, which play pivotal roles in innate immune signaling. The IRAK family includes four members: IRAK1. IRAK2. IRAK3 (IRAK-M), and IRAK4. These serine/threonine kinases are critical mediators downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Upon receptor activation, IRAKs form signaling complexes with adaptor proteins like MyD88. triggering downstream pathways such as NF-κB and MAPK, which drive inflammatory cytokine production.

IRAK4. the most studied member, is unique for its active kinase role in initiating signaling. IRAK1 and IRAK2 amplify signals, while IRAK-M acts as a negative regulator to prevent excessive inflammation. Dysregulation of IRAKs is linked to autoimmune diseases, chronic inflammation, and cancer.

IRAK antibodies are widely used to detect protein expression, phosphorylation status, and interactions in immune cells. They aid in elucidating IRAK-dependent mechanisms in diseases and evaluating therapeutic strategies. For instance, IRAK4 inhibitors are under investigation for treating rheumatoid arthritis, lupus, and certain cancers. However, functional redundancy among IRAK isoforms and their complex regulation pose challenges in drug development.

Overall, IRAK antibodies are indispensable for advancing research on innate immunity and inflammation, bridging molecular insights to potential clinical applications.