Sortilin抗体;Sortilin Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Sortilin expression in SW480 cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

**Background of Sortilin Antibodies**

Sortilin, a member of the vacuolar protein sorting 10 protein (VPS10P) domain receptor family, plays critical roles in intracellular protein trafficking, apoptosis, and receptor signaling. It is involved in neurotrophic signaling, lipid metabolism, and the pathogenesis of neurodegenerative disorders (e.g., Alzheimer’s disease), cardiovascular diseases, and cancer. Sortilin antibodies are essential tools for studying its expression, localization, and functional interactions.

These antibodies target specific epitopes on sortilin, enabling detection via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. They are widely used to investigate sortilin's role in regulating neurotrophin signaling (e.g., proNGF and proBDNF), its interaction with ligands such as progranulin and apolipoprotein E, and its involvement in disease mechanisms. For example, sortilin antibodies have helped identify its contribution to amyloid-β metabolism in Alzheimer’s models and lipid uptake in atherosclerosis.

Commercial sortilin antibodies are typically raised against peptide sequences from the intracellular or extracellular domains. Validation includes testing in knockout cell lines or tissues to confirm specificity. Researchers must select antibodies validated for their specific applications, as cross-reactivity with related VPS10P receptors (e.g., SorLA or SorCS) can occur. Recent studies also utilize sortilin antibodies in therapeutic research, such as targeting sortilin in cancer drug resistance.

Overall, sortilin antibodies are pivotal for unraveling the protein's multifaceted roles in health and disease.