ATPB抗体;ATPB Antibody—艾普蒂

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     Western blot analysis of ATPB expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

ATP synthase beta subunit (ATPB) antibodies are essential tools in studying mitochondrial function and cellular energy metabolism. ATP synthase, a key enzyme in the electron transport chain, catalyzes ATP synthesis during oxidative phosphorylation. The beta subunit (ATPB) forms the catalytic core of the F1 complex, driving ATP production. Antibodies targeting ATPB enable researchers to investigate the expression, localization, and regulation of this subunit across tissues and disease models.

These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess mitochondrial health in conditions such as neurodegenerative disorders, cancer, and metabolic syndromes. Dysregulation of ATPB is linked to mitochondrial dysfunction, making it a biomarker for pathologies involving energy deficits. Additionally, ATPB antibodies aid in exploring drug effects on ATP synthesis or mitochondrial dynamics.

Commercial ATPB antibodies are typically raised against conserved epitopes, ensuring cross-reactivity in human, mouse, and rat samples. Validation includes verifying specificity through knockout controls or siRNA knockdown. Recent studies also utilize these antibodies in proteomic analyses to map protein interactions within ATP synthase complexes. Overall, ATPB antibodies remain critical for dissecting the molecular basis of diseases tied to bioenergetic failure.