Aromatase抗体;Aromatase Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10753(JUND Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10753(JUND Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

Aromatase, also known as cytochrome P450 19A1 (CYP19A1), is a critical enzyme responsible for the conversion of androgens (like testosterone) into estrogens (such as estradiol). This process, termed aromatization, plays a vital role in reproductive physiology, bone health, and neuroendocrine functions. Aromatase is expressed in various tissues, including ovaries, testes, placenta, adipose tissue, and the brain, with its activity tightly regulated by hormonal and tissue-specific factors.

Antibodies targeting aromatase are essential tools for studying its expression, localization, and regulation in both normal and pathological contexts. These antibodies are typically developed against specific epitopes of the enzyme, such as its C-terminal or N-terminal regions, and are available as monoclonal or polyclonal variants. They enable researchers to detect aromatase via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in investigations of conditions like breast cancer (where aromatase-driven estrogen synthesis fuels tumor growth), ovarian dysfunction, and endocrine disorders.

Aromatase antibodies also contribute to understanding species-specific differences, as the enzyme’s structure and activity vary across mammals. Validation using knockout models or siRNA knockdown ensures specificity. In clinical research, these antibodies help evaluate aromatase inhibitor therapies and explore links between estrogen dysregulation and diseases such as osteoporosis or Alzheimer’s. Their utility underscores aromatase’s central role in endocrine signaling and its implications in health and disease.