GC/VDBP抗体;GC/VDBP Antibody—艾普蒂 新品

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     Western blot analysis of GC/VDBP expression in Human plasma lysate.    

  
  

**Background of GC/VDBP Antibodies**

GC (Group-specific Component), also known as Vitamin D-binding protein (VDBP), is a multifunctional glycoprotein synthesized primarily in the liver. It belongs to the albumin gene family and plays a critical role in transporting vitamin D metabolites, including 25-hydroxyvitamin D (25(OH)D) and 1.25-dihydroxyvitamin D (1.25(OH)2D), through the bloodstream to target tissues. Beyond transport, VDBP modulates immune and inflammatory responses by binding to actin released during cell injury and acting as a chemotactic cofactor for complement component C5a.

The human *GC* gene, located on chromosome 4q13.3. exhibits genetic polymorphisms, resulting in three major isoforms (Gc1s, Gc1f, Gc2) that influence vitamin D metabolism and disease susceptibility. Variations in VDBP levels or structure are linked to conditions such as osteoporosis, chronic liver disease, autoimmune disorders, and cancer.

GC/VDBP antibodies are tools used to detect and quantify VDBP in research and clinical settings. They aid in studying vitamin D bioavailability, inflammatory pathways, and disease mechanisms. Autoantibodies targeting VDBP have also been reported in certain autoimmune conditions, suggesting a potential role in pathophysiology. These antibodies are essential for elucidating VDBP’s diverse roles in health and disease.