58KGolgiprotein抗体;58KGolgiprotein Antibody—艾普蒂 新品

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     Western blot analysis of 58K Golgi protein expression in human fetal liver lysate.    

  
  

The 58K Golgi protein, also known as Golgin-45 or GCP60. is a peripheral membrane protein primarily localized to the Golgi apparatus. It plays a critical role in maintaining Golgi structure and facilitating vesicular trafficking, particularly in the early secretory pathway. The protein interacts with other Golgi-associated proteins, such as GRASP65 and GM130. to regulate cis-Golgi network organization and cargo transport. Its 58 kDa molecular weight reflects its functional domains, including coiled-coil regions that mediate protein-protein interactions.

Antibodies targeting the 58K Golgi protein are widely used in cell biology research to study Golgi dynamics, fragmentation during mitosis, and responses to cellular stress or pharmacological agents. These antibodies enable techniques like immunofluorescence, Western blotting, and immunoprecipitation, helping visualize Golgi morphology or investigate protein interactions. Dysregulation of the 58K Golgi protein has been implicated in diseases such as cancer, where altered Golgi function may promote invasiveness, and neurodegenerative disorders linked to secretory pathway defects.

First characterized in the 1990s, the 58K Golgi protein antibody remains a key tool for probing Golgi-related mechanisms in membrane trafficking, apoptosis, and cellular adaptation. Recent studies also explore its potential role in chemoresistance, as Golgi stress responses influence cancer cell survival. Its conserved structure across mammals underscores its functional importance in fundamental cell processes.