Myosinheavychain抗体;Myosinheavychain Antibody—艾普蒂

+ +

•  

   

     Western blot analysis of Myosin heavy chain expression in mouse heart lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using Myosin heavy chain Antibody.    

  
  

Myosin heavy chain (MHC) antibodies are essential tools in studying the structure, function, and diversity of myosin proteins, which are critical components of muscle contraction. Myosin is a motor protein composed of heavy and light chains, with the heavy chain determining its isoform-specific properties. MHC exists in multiple isoforms encoded by distinct genes, including slow-twitch (Type I, e.g., MHC-β/Myh7) and fast-twitch (Type IIa/Myh2. IIx/Myh1. IIb/Myh4) variants in skeletal muscle, as well as cardiac-specific isoforms (e.g., α-MHC/Myh6 and β-MHC/Myh7). These isoforms dictate contractile speed, metabolic efficiency, and functional specialization across muscle types.

MHC antibodies are widely used to identify muscle fiber types in research on skeletal muscle plasticity, cardiac hypertrophy, and neuromuscular disorders. For example, antibodies targeting MHC-I highlight slow, oxidative fibers involved in endurance, while those against MHC-II detect fast, glycolytic fibers associated with explosive movements. In cardiac research, shifts between α- and β-MHC isoforms serve as biomarkers for pathological remodeling. Additionally, MHC antibodies aid in diagnosing myopathies, monitoring muscle regeneration (via embryonic/neonatal MHC isoforms), and studying evolutionary conservation across species. Their specificity enables precise localization in techniques like immunohistochemistry, Western blotting, and flow cytometry. Commercial availability and well-characterized epitopes make MHC antibodies indispensable in muscle physiology, disease modeling, and therapeutic development.