VECadherin抗体;VECadherin Antibody—艾普蒂

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     Western blot analysis of VE Cadherin expression in Mouse lung lysate.    

  
  

VE-cadherin (Vascular Endothelial cadherin), also known as CDH5 or CD144. is a calcium-dependent transmembrane protein critical for maintaining endothelial cell-cell adhesion. As a key component of endothelial adherens junctions, it mediates homophilic interactions between adjacent cells through its extracellular cadherin repeats, while its intracellular domain binds to catenins (e.g., β-catenin) to link the actin cytoskeleton. This structural role stabilizes vascular integrity, regulates vascular permeability, and supports angiogenesis. Dysregulation of VE-cadherin is implicated in pathological conditions such as inflammation, tumor angiogenesis, and atherosclerosis.

VE-cadherin antibodies are indispensable tools for studying endothelial biology. They enable detection of VE-cadherin expression and localization via techniques like immunohistochemistry, immunofluorescence, and Western blotting. Function-blocking antibodies are widely used to disrupt VE-cadherin-mediated adhesion in vitro, revealing its role in endothelial barrier function, leukocyte transmigration, and vascular remodeling. In disease research, these antibodies help assess vascular abnormalities in cancer models or inflammatory disorders. Additionally, therapeutic applications are being explored, including targeting VE-cadherin to modulate vascular permeability in edema or inhibit pathological angiogenesis. Validation of antibody specificity remains crucial due to structural similarities among cadherin family members. Overall, VE-cadherin antibodies continue to advance both basic research and translational studies in vascular biology.