EstrogenReceptorbeta抗体;EstrogenReceptorbeta Antibody—艾普蒂

+ +

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human cervix cancer, using Estrogen Receptor beta Antibody.    

  
  

The estrogen receptor beta (ERβ) antibody is a critical tool in biomedical research for detecting and studying the ERβ protein, a key mediator of estrogen signaling. ERβ, one of two main estrogen receptor subtypes (alongside ERα), is encoded by the *ESR2* gene and plays diverse roles in regulating cellular processes such as proliferation, differentiation, and apoptosis. While ERα is predominantly associated with reproductive tissues, ERβ is widely expressed in non-reproductive organs, including the brain, cardiovascular system, and immune cells, implicating it in broader physiological and pathological functions.

ERβ-specific antibodies enable researchers to map its expression patterns, investigate its role in diseases like cancer (e.g., breast, prostate), and explore its potential as a therapeutic target. These antibodies are widely used in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence. However, challenges persist in ensuring antibody specificity due to structural similarities between ERβ and ERα, as well as splice variants of ERβ. Variability in antibody performance across commercial clones and tissue fixation methods has led to discrepancies in published data, underscoring the need for rigorous validation using controls like knockout models or siRNA.

Recent studies highlight ERβ's context-dependent roles, including tumor-suppressive effects in certain cancers and neuroprotective functions. Advances in antibody validation and the development of isoform-selective probes continue to refine our understanding of ERβ's biological and clinical significance.