Hsp105抗体;Hsp105 Antibody—艾普蒂

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     Western blot analysis of Hsp105 expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

Hsp105 (Heat Shock Protein 105) is a member of the HSP70/HSP110 molecular chaperone family, playing a critical role in cellular stress responses and protein homeostasis. Primarily induced under stress conditions such as heat shock, oxidative stress, or proteotoxic insults, Hsp105 assists in protein folding, prevents aggregation of misfolded proteins, and facilitates their refolding or degradation. Structurally, it contains an N-terminal ATPase domain and a C-terminal substrate-binding domain, enabling its chaperone activity through ATP-dependent conformational changes.

Hsp105 exists in two major isoforms: the stress-inducible HSP105α and the constitutively expressed HSP105β. These isoforms exhibit distinct regulatory roles, with HSP105α predominantly activated during stress to enhance cell survival, while HSP105β contributes to basal protein quality control. Dysregulation of Hsp105 has been implicated in neurodegenerative diseases (e.g., Alzheimer's, Huntington's) due to its interaction with pathogenic protein aggregates, as well as in cancer, where it may promote tumor progression by supporting cancer cell survival under microenvironmental stress.

Antibodies targeting Hsp105 are essential tools for investigating its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study stress response mechanisms, disease pathology, and therapeutic targeting. Commercially available antibodies often distinguish between isoforms or post-translationally modified forms, enabling precise research into Hsp105's dual roles as a cytoprotective agent and potential disease driver. Recent studies also explore its diagnostic potential as a biomarker in cancers and neurodegenerative disorders.