CDC42EP1抗体;CDC42EP1 Antibody—艾普蒂

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     Western blot analysis of CDC42EP1 expression in HUVEC cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The CDC42EP1 antibody is a research tool designed to detect the CDC42 effector protein 1 (CDC42EP1), a member of the CDC42EP/BORG family that interacts with the small GTPase CDC42. CDC42EP1. also known as BORG1 or CEP1. plays a role in regulating cytoskeletal dynamics, cell morphology, and polarity by coordinating actin and microtubule networks. It binds to activated CDC42. facilitating the assembly of protein complexes that influence cell migration, adhesion, and junction formation.

This antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study CDC42EP1 expression, localization, and function in various cell types and tissues. Its specificity is validated through knockout controls or siRNA-mediated depletion. CDC42EP1 is structurally characterized by its Bem1 homology (BH) domains and CDC42-binding motifs, enabling interactions with downstream effectors.

Research highlights its involvement in pathological processes, including cancer progression, where altered expression correlates with metastasis, and inflammatory diseases due to its role in immune cell regulation. Studies also link CDC42EP1 to neurological disorders and developmental defects. The antibody aids in elucidating its molecular mechanisms, offering insights into therapeutic targeting of CDC42-related pathways. Proper validation ensures minimal cross-reactivity with other BORG family members, critical for accurate experimental interpretation.