PAX7抗体;PAX7 Antibody—艾普蒂

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The PAX7 antibody is a valuable tool in developmental biology and cancer research, targeting the paired box protein PAX7—a transcription factor crucial for embryogenesis. PAX7 belongs to the PAX family of proteins characterized by a conserved paired box DNA-binding domain and a transcriptional activation domain. It plays a pivotal role in neural crest development, skeletal muscle stem cell (satellite cell) specification, and maintenance. During muscle regeneration, PAX7 is essential for satellite cell proliferation and differentiation, making its antibody a key reagent for identifying and studying muscle stem cells in tissues or cultures.

In research, PAX7 antibodies are widely used in techniques like immunohistochemistry, immunofluorescence, and flow cytometry to localize and quantify PAX7-expressing cells. Commercially available monoclonal and polyclonal variants vary in specificity, often validated across species (human, mouse, rat). Aberrant PAX7 expression is linked to cancers such as alveolar rhabdomyosarcoma and neuroblastoma, where it may drive oncogenesis or indicate poor prognosis. However, its role remains context-dependent; in melanoma, PAX7 downregulation correlates with metastasis.

Researchers also utilize PAX7 antibodies to explore regenerative medicine strategies and tumor heterogeneity. Cross-reactivity with other PAX family members (e.g., PAX3) requires careful validation to ensure experimental accuracy. Overall, PAX7 antibodies bridge mechanistic insights into developmental pathways and disease mechanisms, with diagnostic and therapeutic potential.