Phospho-JunD(S255)抗体;Phospho-JunD(S255) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-JunD (S255) expression in (1) HeLa cell lysate treated with Alkaline Phosphatase; (2) HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The Phospho-JunD(S255) antibody is a specialized tool used to detect JunD protein phosphorylated at serine residue 255. a post-translational modification critical for regulating JunD's functional interactions. JunD, a member of the AP-1 (Activator Protein-1) transcription factor family, plays diverse roles in cellular processes such as proliferation, differentiation, and apoptosis. Unlike other Jun family members (c-Jun, JunB), JunD is often associated with anti-proliferative or stress-adaptive responses. Phosphorylation at specific residues, including S255. modulates its stability, DNA-binding capacity, and interaction with partner proteins like Fos family members to form functional AP-1 complexes.

The S255 phosphorylation site lies within the regulatory domain of JunD, and its modification is implicated in signaling pathways triggered by extracellular stimuli, such as growth factors, cytokines, or stress signals. This antibody is commonly used in research to investigate JunD activation dynamics in contexts like cancer, inflammation, or neurodegenerative diseases. It enables detection of phosphorylated JunD via techniques like Western blotting, immunofluorescence, or immunohistochemistry, helping elucidate its role in cellular responses to oxidative stress, DNA damage, or oncogenic signaling. Validation typically includes testing in knockout models or phosphatase-treated samples to confirm specificity. Understanding JunD phosphorylation patterns contributes to insights into disease mechanisms and potential therapeutic targets.