ATF5抗体;ATF5 Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of ATF5 expression in (1) Jurkat cell lysate; (2) 3T3 cell lysate; (2) C6 cell lysate.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:150 dilution.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Human breast, using ATF5 Antibody.    

  
  

ATF5 (Activating Transcription Factor 5) is a member of the cAMP response element-binding (CREB)/ATF family of transcription factors, which regulates gene expression in response to cellular stress, proliferation, and differentiation. It plays a critical role in maintaining cellular homeostasis, particularly in secretory cells, neurons, and cancer. ATF5 is activated under stress conditions such as endoplasmic reticulum (ER) stress, amino acid deprivation, or oxidative stress, where it modulates adaptive pathways to promote cell survival or apoptosis, depending on context.

ATF5 antibodies are essential tools for studying its expression, localization, and function. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ATF5 protein levels in tissues or cultured cells. Researchers employ them to explore ATF5's involvement in diseases, including cancer (e.g., glioblastoma, breast cancer), neurodegenerative disorders, and metabolic syndromes. Specific ATF5 antibodies may target distinct epitopes or isoforms, requiring validation for species cross-reactivity and application suitability.

Studies using ATF5 antibodies have revealed its oncogenic potential, such as promoting tumor cell survival and chemoresistance, making it a therapeutic target. Conversely, in neural systems, ATF5 supports neuronal differentiation and survival. Continuous development and optimization of ATF5 antibodies enhance their specificity, aiding mechanistic insights into stress adaptation and disease pathology.