Cdk7抗体;Cdk7 Antibody—艾普蒂

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     Western blot analysis of CDK7 expression in MCF-7 cell lysate.    

  
  

CDK7 (Cyclin-Dependent Kinase 7) is a serine/threonine kinase belonging to the CDK family, playing dual roles in cell cycle regulation and transcriptional control. As a core component of the CDK-activating kinase (CAK) complex, CDK7 phosphorylates and activates CDKs (e.g., CDK1. CDK2. CDK4. CDK6) that drive cell cycle progression. Additionally, it is part of the general transcription factor TFIIH, where it phosphorylates the C-terminal domain (CTD) of RNA polymerase II to facilitate transcription initiation. Dysregulation of CDK7 is linked to cancers, neurodegenerative diseases, and developmental disorders, making it a therapeutic target.

CDK7 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess CDK7 levels in tissues or cells, often correlating its activity with disease states. In cancer research, these antibodies help evaluate CDK7 overexpression in tumors and monitor responses to CDK7 inhibitors (e.g., THZ1). They also aid in exploring CDK7's non-canonical roles, such as modulating epigenetic regulators. Validated CDK7 antibodies ensure specificity for distinguishing CDK7 from other CDKs, supporting both basic research and drug development. Their applications extend to screening biomarkers and understanding resistance mechanisms in targeted therapies.