PKC抗体;PKC Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:1K dilution)    

  
  

Protein kinase C (PKC) antibodies are essential tools for studying the PKC family of serine/threonine kinases, which play pivotal roles in cellular signaling pathways. PKC enzymes regulate diverse processes, including cell proliferation, differentiation, apoptosis, and immune responses. The PKC family consists of multiple isoforms (e.g., PKC-α, -β, -γ, -δ), categorized into classical, novel, and atypical subfamilies based on their activation mechanisms. Dysregulation of PKC activity is linked to cancers, neurological disorders, and metabolic diseases, driving interest in their molecular functions.

PKC antibodies are designed to detect specific isoforms or phosphorylation states, enabling researchers to analyze expression levels, localization, and activation status in tissues or cells. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Selective antibodies help elucidate isoform-specific roles, such as PKC-δ in apoptosis or PKC-β in diabetic complications. Additionally, PKC inhibitors/activators are explored as therapeutics, making these antibodies critical for validating drug targets and understanding mechanisms in preclinical models.

Challenges include cross-reactivity due to isoform homology, necessitating rigorous validation. Advances in monoclonal antibody technology have improved specificity, supporting precise research into PKC-related pathologies and signaling networks.