PRP19抗体;PRP19 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of PRP19 expression in (1) HepG2 cell lysate; (2) NIH/3T3 cell lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervix cancer, using PRP19 Antibody.    

  
  

The PRP19 antibody targets the PRP19 protein (Precursor RNA Processing 19), a key component of the spliceosome involved in pre-mRNA splicing. PRP19. also known as PSO4 or NMP200. is a ubiquitin ligase critical for maintaining spliceosome stability during catalytic activation and disassembly. It forms the PRP19-associated complex (NTC, NineTeen Complex) with other proteins (e.g., CDC5L, SPF27), facilitating spliceosome remodeling and ensuring splicing fidelity. Beyond splicing, PRP19 participates in DNA damage repair, cell cycle regulation, and telomere maintenance, highlighting its multifunctional role.

PRP19 antibodies are widely used in molecular biology to study spliceosome dynamics, protein interactions, and subcellular localization. They are essential tools in Western blotting, immunoprecipitation, and immunofluorescence to investigate PRP19’s expression and function in diseases. Dysregulation of PRP19 is linked to cancer (e.g., overexpression in tumors), neurodegeneration, and developmental disorders, making it a potential therapeutic target. These antibodies often exhibit cross-reactivity across species (human, mouse, rat) and are available as monoclonal or polyclonal variants. Research utilizing PRP19 antibodies continues to unravel its dual roles in RNA processing and genome stability, advancing insights into disease mechanisms and RNA-targeted therapies.