Phospho-PDGFReceptorbeta(Y740)抗体;Phospho-PDGFReceptorbeta(Y740) Antibody—艾普蒂 新品

The Phospho-PDGFReceptor beta (Y740) antibody is a key tool for studying the activation status of platelet-derived growth factor receptor beta (PDGFRβ), a receptor tyrosine kinase critical for cellular processes like proliferation, migration, and survival. PDGFRβ is activated upon binding to PDGF ligands, leading to receptor dimerization, autophosphorylation of specific tyrosine residues, and downstream signaling. Phosphorylation at tyrosine 740 (Y740) occurs within the kinase domain and serves as a docking site for adaptor proteins, particularly those containing SH2 domains, which propagate signaling through pathways such as PI3K/Akt and Ras/MAPK. This phosphorylation event is tightly regulated and often dysregulated in pathological conditions, including cancers, fibrosis, and atherosclerosis. The antibody specifically detects PDGFRβ phosphorylated at Y740. enabling researchers to assess receptor activation in response to stimuli or therapeutic interventions. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study PDGFRβ signaling dynamics in cell lines, tissue samples, or disease models. Its applications extend to both basic research and drug development, particularly in contexts targeting PDGFRβ-driven oncogenesis or tissue remodeling. Validation typically includes testing in phosphorylated vs. non-phosphorylated states to ensure specificity.