ACC1抗体;ACC1 Antibody—艾普蒂

Acetyl-CoA carboxylase 1 (ACC1), encoded by the ACACA gene, is a biotin-dependent enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a rate-limiting step in fatty acid synthesis. It plays a central role in lipid metabolism by regulating the balance between fatty acid synthesis (cytosolic ACC1) and oxidation (mitochondrial ACC2). ACC1 is highly expressed in lipogenic tissues like liver and adipose, and its activity is tightly regulated by phosphorylation (e.g., AMPK-mediated inhibition) and allosteric modifiers. Dysregulation of ACC1 is linked to metabolic disorders (obesity, diabetes), cancer (enhanced lipogenesis supports tumor growth), and cardiovascular diseases. ACC1 antibodies are essential tools for studying its expression, post-translational modifications, and subcellular localization in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ACC1's role in disease mechanisms or therapeutic targeting. Notably, ACC1 inhibitors are under investigation for metabolic and oncological therapies, making specific antibodies critical for validating target engagement and biomarker analysis in preclinical studies.