Rab9抗体;Rab9 Antibody—艾普蒂

+ +

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

•  

   

     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

Rab9 antibodies are essential tools in cellular biology for studying the function and localization of Rab9. a small GTPase belonging to the Rab family. Rab9 regulates intracellular membrane trafficking, particularly in the late endosome-to-trans-Golgi network (TGN) and endosome-to-lysosome pathways. It plays a critical role in maintaining lysosomal function by facilitating the transport of mannose 6-phosphate receptors (MPRs) and other cargo. Dysregulation of Rab9 is linked to lysosomal storage disorders, neurodegenerative diseases, and viral infections (e.g., HIV-1), as some pathogens exploit Rab9-mediated pathways for replication or immune evasion.

Rab9 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect Rab9 expression, subcellular distribution, and interactions. They help elucidate Rab9's role in membrane dynamics, autophagy, and disease mechanisms. Polyclonal and monoclonal variants are available, typically raised in hosts like mice or rabbits. Specificity validation (e.g., knockout controls) is crucial due to potential cross-reactivity with other Rab proteins. Commercial antibodies often cite applications in research areas such as cancer, lipid metabolism, and infection biology. Recent studies also explore Rab9's involvement in extracellular vesicle biogenesis and cellular stress responses, expanding its relevance in biomedical research.