c-Maf抗体;c-Maf Antibody—艾普蒂

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     Immunohistochemical analysis of paraffin-embedded human kidney, using c-Maf Antibody.    

  
  

c-Maf antibodies are essential tools for studying the transcription factor c-Maf, a member of the large Maf protein family. c-Maf (cellular musculoaponeurotic fibrosarcoma oncogene homolog) regulates gene expression by binding to Maf recognition elements (MAREs) in DNA. It plays critical roles in cellular differentiation, immune regulation, and tissue development. Notably, c-Maf is involved in T-cell subset differentiation (e.g., Th17 cells) and the maintenance of immune tolerance. It also contributes to the development of plasma cells and lens fiber cells. Dysregulation of c-Maf is linked to diseases, including multiple myeloma, where its overexpression promotes oncogenesis, and autoimmune disorders.

c-Maf antibodies are widely used in research to detect and quantify c-Maf protein levels in cells or tissues via techniques like Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate c-Maf's role in signaling pathways, disease mechanisms, and potential therapeutic targets. Commercial antibodies are typically raised against specific epitopes of human or mouse c-Maf, with validation in knockout controls to ensure specificity. Researchers must select antibodies based on host species, clonality (monoclonal/polyclonal), and compatibility with intended applications. Reliable c-Maf antibodies are crucial for advancing studies in immunology, cancer biology, and developmental biology, making them indispensable for both basic research and clinical diagnostics.