Ceruloplasmin抗体;Ceruloplasmin Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Ceruloplasmin expression in Rat liver cell lysate.    

  
  

Ceruloplasmin is a copper-binding glycoprotein primarily synthesized in the liver, playing a critical role in iron and copper homeostasis. As a multi-copper oxidase, it facilitates iron export from cells by oxidizing ferrous iron (Fe²⁺) to ferrous (Fe³⁺), enabling its binding to transferrin. It also transports 90-95% of circulating copper, making it essential for preventing copper toxicity and supporting enzymatic functions. Ceruloplasmin antibodies are immunoglobulins developed to detect or quantify this protein in biological samples, serving as key tools in research and diagnostics.

In clinical contexts, ceruloplasmin antibodies are employed to measure serum ceruloplasmin levels, aiding in diagnosing disorders like Wilson’s disease—a genetic condition characterized by copper accumulation due to ceruloplasmin dysfunction. Low ceruloplasmin, detected via immunoassays (e.g., ELISA, immunoturbidimetry), is a hallmark of this disease. Antibodies also help identify aceruloplasminemia, a rare iron metabolism disorder caused by ceruloplasmin gene mutations, leading to neurodegenerative symptoms and diabetes.

Research applications include studying ceruloplasmin’s role in inflammation, oxidative stress, and cancer, where its expression may correlate with disease progression. Monoclonal and polyclonal antibodies enable precise localization in tissues (via immunohistochemistry) or quantification in fluids. Additionally, they assist in exploring ceruloplasmin’s dual role as both a protective antioxidant and a potential contributor to pathological processes under dysregulated conditions. These antibodies thus bridge mechanistic insights into metal metabolism disorders and therapeutic development.