SHB抗体;SHB Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of SHB expression in K562 cell lysate.    

  
  

SHB antibody targets the SH2 domain-containing adapter protein B (SHB), a signaling molecule involved in various cellular processes. SHB contains multiple functional domains, including a phosphotyrosine-binding SH2 domain, which enables interaction with phosphorylated tyrosine residues on activated receptors or intracellular kinases. It plays a regulatory role in growth factor signaling pathways (e.g., VEGF, FGF, PDGF) and modulates downstream processes like cell proliferation, differentiation, migration, and apoptosis. SHB is expressed across tissues and implicated in angiogenesis, insulin secretion, and immune responses.

SHB antibodies are essential tools for studying its expression, localization, and interactions in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate SHB's role in cancer progression, diabetes, cardiovascular diseases, and developmental disorders. Research has linked SHB dysregulation to tumor angiogenesis, metastasis, and impaired β-cell function, making it a potential therapeutic target. Commercial SHB antibodies are typically developed in rabbits or mice, validated for specificity via knockout controls. Their application advances understanding of SHB's multifaceted signaling networks and disease mechanisms.