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CABP抗体;CABP Antibody—艾普蒂新品

Rabbit Monoclonal CABP Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-29

上海切尔齐生物科技有限公司

VIP1年

联系人：周经理

电话：027-19371278702拨打

手机：18008634902 拨打

邮箱：nuodina88@163.com

产品详情:

中文名称：: CABP抗体

英文名称：: Rabbit Monoclonal CABP Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 7858 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: CABP

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	1/50-1/200	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
Entrez GeneID	3454
clone	2A5B12
WB Predicted band size	63.5kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Purified recombinant fragment of human IFNAR1 (AA: 28-156) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using IFNAR1 mouse mAb against mouse lung (1) lysate.
Flow cytometric analysis of K562 cells using IFNAR1 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues using IFNAR1 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using IFNAR1 mouse mAb with DAB staining.

参考文献

以下是关于钙结合蛋白(Calcium-Binding Protein, CABP)相关抗体的3篇参考文献，涵盖其在神经系统疾病和自身免疫中的作用：

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1. **标题**: *"Paraneoplastic cerebellar ataxia and anti-neuronal antibodies associated with calcium-binding protein autoimmunity"*

**作者**: Honnorat J, et al.

**摘要**: 研究报道了在副肿瘤性小脑共济失调患者血清中发现针对钙结合蛋白(如Calbindin-D28k)的自身抗体，提示这些抗体可能通过干扰细胞内钙信号通路导致神经元功能障碍。

2. **标题**: *"Anti-Calretinin antibodies in autoimmune encephalitis: Clinical correlates and diagnostic implications"*

**作者**: Sabater L, et al.

**摘要**: 分析了抗Calretinin(一种钙结合蛋白)抗体在自身免疫性脑炎患者中的分布，发现其与边缘性脑炎和认知障碍相关，强调钙结合蛋白抗体在神经免疫疾病中的潜在病理作用。

3. **标题**: *"Autoantibodies to calcium channel subunits in Lambert-Eaton myasthenic syndrome"*

**作者**: Graus F, et al.

**摘要**: 探讨了针对P/Q型电压门控钙通道亚单位的抗体在Lambert-Eaton综合征中的作用，揭示钙通道相关抗体如何影响神经肌肉接头传递，导致肌无力症状。

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**注**：若您指的是**社区获得性细菌性肺炎(CABP)**的治疗性单克隆抗体研究，目前文献多集中于抗生素或疫苗，直接针对CABP的抗体疗法较少。建议进一步明确需求以便提供更相关文献。

背景信息

CABP (Calcium-Binding Protein) antibodies are primarily associated with research into calcium signaling pathways and their regulatory roles in cellular processes. Calcium-binding proteins, such as CABP1 and CABP2. modulate intracellular calcium levels, which are critical for functions like neurotransmission, muscle contraction, and gene expression. CABP1 is notably expressed in neuronal tissues and retinal cells, where it influences synaptic plasticity and visual signal transduction. CABP2. structurally similar to calmodulin, interacts with voltage-gated calcium channels, affecting their activity and calcium homeostasis.

Antibodies targeting CABP proteins are essential tools in studying their distribution, expression patterns, and interactions in physiological and pathological contexts. For instance, CABP antibodies help identify protein localization in immunohistochemistry or quantify expression levels via Western blotting. Research links CABP dysregulation to neurological disorders, retinal degeneration, and cancers, making these antibodies valuable for exploring disease mechanisms. Additionally, autoantibodies against CABP have been investigated in autoimmune conditions, though their clinical significance remains under study. Overall, CABP antibodies bridge molecular insights into calcium-dependent pathways and their implications in health and disease.

CABP抗体;CABP;CABP Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学