PSIP1/LEDGF抗体;PSIP1/LEDGF Antibody—艾普蒂 新品

+ +

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     Western blot analysis of PSIP1 / LEDGF expression in HeLa cell lysate.    

  
  

The PSIP1/LEDGF (PC4 and SFRS1 Interacting Protein 1/Lens Epithelium-Derived Growth Factor) antibody targets a multifunctional protein involved in transcriptional regulation, stress response, and chromatin remodeling. Initially identified as a growth factor in lens epithelial cells, LEDGF/p75 (encoded by PSIP1) is now recognized for its role in tethering HIV-1 integrase to host chromatin, facilitating viral DNA integration. It contains conserved domains, including an N-terminal PWWP chromatin-binding domain and a C-terminal integrase-binding domain, making it critical in HIV pathogenesis and a potential therapeutic target.

Antibodies against PSIP1/LEDGF are widely used in research to study its interaction with HIV-1 integrase, chromatin-associated complexes, and its role in leukemia, where it frequently partners with MLL fusion proteins. These antibodies (monoclonal or polyclonal) enable detection via techniques like Western blot, immunofluorescence, and immunohistochemistry. They also help explore LEDGF’s oncogenic functions, as its overexpression is linked to poor prognosis in cancers like prostate cancer and leukemia. Additionally, PSIP1/LEDGF antibodies contribute to investigations of autoimmunity, as autoantibodies against LEDGF are observed in inflammatory conditions like uveitis. Research continues to focus on modulating LEDGF interactions for antiviral and anticancer therapies.