GSTA4抗体;GSTA4 Antibody—艾普蒂

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of GSTA4 expression in 293T cell lysate.    

  
  

**Background of GSTA4 Antibody**

The glutathione S-transferase alpha 4 (GSTA4) antibody is a tool used to detect and study the GSTA4 protein, a member of the glutathione S-transferase (GST) family. GSTs are phase II detoxification enzymes that catalyze the conjugation of glutathione to electrophilic substrates, facilitating the elimination of toxic compounds, including reactive oxygen species (ROS) and lipid peroxidation byproducts. GSTA4. specifically, is part of the alpha-class GST subfamily and is distinguished by its high efficiency in metabolizing 4-hydroxynonenal (4-HNE), a cytotoxic aldehyde generated during lipid peroxidation. This enzyme plays a critical role in cellular defense against oxidative stress and is implicated in pathways linked to aging, inflammation, and diseases such as cancer, diabetes, and neurodegenerative disorders.

The GSTA4 antibody is widely employed in research to investigate protein expression levels, subcellular localization (e.g., mitochondrial and cytoplasmic distribution), and regulatory mechanisms in various tissues. It is utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies using this antibody have revealed GSTA4's tissue-specific expression patterns and its potential as a biomarker for oxidative damage or therapeutic response. Commercial GSTA4 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human or rodent GSTA4 protein. Validation includes testing for cross-reactivity with other GST isoforms to ensure specificity. Understanding GSTA4's function through antibody-based research contributes to insights into cellular redox homeostasis and disease pathogenesis.