QPCT抗体;QPCT Antibody—艾普蒂

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     IHC-P analysis of adrenal gland tissue by QPCT antibody (P15737) IHC-P was performed using sections of the formalin-fixed paraffin-embedded adrenal gland tissue;Result: Glandular cells are positively stained at the cytoplasm and cell membrane.    

  
  

QPCT (glutaminyl-peptide cyclotransferase) antibodies are tools used to study the enzyme QPCT, which catalyzes the formation of N-terminal pyroglutamate (pGlu) residues in peptides and proteins. This post-translational modification enhances protein stability, modulates biological activity, and influences interactions with receptors or binding partners. QPCT, also known as QC, plays a critical role in pathological processes such as neuroinflammation and neurodegeneration. For example, it contributes to the generation of neurotoxic pyroglutamate-modified β-amyloid (Aβ-pE3) aggregates in Alzheimer’s disease. Dysregulation of QPCT has also been linked to cancer, diabetes, and inflammatory disorders.

Antibodies targeting QPCT are essential for detecting its expression, localization, and activity in cells and tissues. They enable applications like Western blotting, immunohistochemistry, and ELISA, aiding in mechanistic studies of QPCT-related diseases. Additionally, these antibodies support drug discovery efforts, particularly in developing QPCT inhibitors as potential therapeutics. For instance, inhibiting QPCT may reduce Aβ-pE3 accumulation, offering a strategy to slow Alzheimer’s progression. Researchers also use QPCT antibodies to explore its role in chemokine regulation (e.g., CCL2. CX3CL1) and immune cell migration. Overall, QPCT antibodies are vital for advancing understanding of its biological functions and therapeutic targeting in multiple diseases.