DRAXIN抗体;DRAXIN Antibody—艾普蒂 新品

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     IHC-P analysis of brain tissue by KLH antibody (P15721) IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue;Result: Neuronal cells are positively stained at the cytoplasm.    

  
  

DRAXIN (dorsal repulsive axon guidance protein) is a secreted axon guidance molecule first identified in vertebrates for its role in neural development, particularly in establishing neuronal circuit connectivity. Discovered in the early 2010s, DRAXIN is known to mediate repulsive signaling during axon pathfinding, working in concert with other guidance cues like Netrin-1 and members of the Slit-Robo pathway. It is prominently expressed in the dorsal spinal cord and developing brain, where it helps regulate commissural axon trajectories by repelling specific neuronal populations, ensuring precise wiring of neural networks.

DRAXIN antibodies are tools developed to study its expression, localization, and functional interactions. These antibodies enable researchers to visualize DRAXIN distribution in tissues, assess its binding partners, and dissect its role in axon guidance through loss- or gain-of-function experiments. Studies using DRAXIN antibodies have highlighted its involvement in embryonic neural patterning and potential links to neurodevelopmental disorders. Additionally, DRAXIN's interaction with the Netrin-1 receptor DCC (Deleted in Colorectal Cancer) underscores its broader relevance in balancing attraction and repulsion during axon guidance. While research on DRAXIN remains niche, its antibodies are critical for unraveling mechanisms underlying neural circuit assembly and developmental brain disorders.