CEP43抗体;CEP43 Antibody—艾普蒂 新品

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     IHC-P analysis of testis tissue by CEP43 antibody (P15676) IHC-P was performed using sections of the formalin-fixed paraffin-embedded testis tissue;Result: Cells in seminiferous ducts are positively stained at the cytoplasm.    

  
  

The CEP43 antibody targets the centrosomal protein CEP43 (also known as CCDC19), which plays a role in centrosome structure and function. Centrosomes are microtubule-organizing centers critical for cell division, cilia formation, and intracellular transport. CEP43 is implicated in maintaining centrosome integrity and regulating mitotic spindle orientation, processes essential for proper chromosome segregation and cell cycle progression. Dysregulation of centrosomal proteins, including CEP43. has been linked to genomic instability, developmental disorders, and cancers.

CEP43 antibodies are primarily used in research to study centrosome biology, ciliopathies, and cancer mechanisms. They enable detection and localization of CEP43 in cells via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Studies utilizing these antibodies have explored CEP43's interaction with other centrosomal components, its role in ciliogenesis, and its potential as a biomarker in diseases.

The antibody's specificity and validation are crucial, as cross-reactivity with other centrosomal proteins can complicate interpretations. Recent research continues to investigate CEP43's molecular functions, particularly its contribution to cellular responses to DNA damage and its association with microtubule dynamics, highlighting its broader relevance in cell biology and pathology.