WASL抗体;WASL Antibody—艾普蒂

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     Lane 1: Mouse brain tissue lysate ;  Lane 2: WASL immunoprecipitated from mouse brain tissue lysate by P15674 ;  Lane 3: The same  Lane 2 but use  IgG isotype control antibody ;Result: P15674 can immunoprecipitate WASL;    

  
  

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     IHC-P analysis of small intestine tissue by WASL antibody (P15674) IHC-P was performed using sections of the formalin-fixed paraffin-embedded small intestine tissue;Result: Glandular cells are positively stained at the cytoplasm and nuclei.    

  
  

WASL (Wiskott-Aldrich Syndrome-like) protein, also known as N-WASP (Neuronal Wiskott-Aldrich Syndrome Protein), is a key regulator of actin cytoskeleton dynamics. It belongs to the WASP family of proteins, which play critical roles in cell motility, membrane trafficking, and immune synapse formation. WASL contains multiple functional domains, including a Cdc42-binding region, a proline-rich motif for SH3 domain interactions, and a C-terminal verprolin-cofilin-acidic (VCA) domain that activates the Arp2/3 complex to nucleate actin filaments. Dysregulation of WASL is linked to cellular processes such as cancer metastasis, viral pathogenesis, and neurological disorders.

Antibodies targeting WASL are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate WASL's role in signaling pathways, particularly those involving Rho GTPases (e.g., Cdc42) and actin remodeling. In clinical contexts, WASL antibodies aid in diagnosing conditions associated with cytoskeletal abnormalities, including neurodevelopmental disorders and immune deficiencies. Recent research also explores WASL's involvement in autophagy and intracellular pathogen invasion, highlighting its therapeutic potential. Validated antibodies with high specificity are crucial, as cross-reactivity with other WASP family members (e.g., WASP, WAVE) may lead to experimental ambiguity.