CHCHD6抗体;CHCHD6 Antibody—艾普蒂

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     Lane 1: Jurkat lysate ;  Lane 2: CHCHD6 immunoprecipitated from Jurkat lysate by P15577 ;  Lane 3: The same  Lane 2 but use  IgG isotype control antibody ;Result: P15577 can immunoprecipitate CHCHD6;    

  
  

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     IHC-P analysis of stomach tissue by CHCHD6 antibody (P15577) IHC-P was performed using sections of the formalin-fixed paraffin-embedded stomach tissue;Result: Glandular cells are positively stained at the cytoplasm.    

  
  

The CHCHD6 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) antibody is a tool used to detect and study the CHCHD6 protein, a member of the CHCHD family implicated in mitochondrial function and cellular stress responses. CHCHD6 localizes primarily to mitochondria and interacts with components of the mitochondrial contact site and cristae organizing system (MICOS), playing roles in maintaining cristae structure, energy metabolism, and apoptosis regulation. Dysregulation of CHCHD6 has been linked to neurodegenerative diseases, cancer, and metabolic disorders due to its involvement in oxidative stress pathways and mitochondrial dynamics.

The CHCHD6 antibody enables researchers to investigate these mechanisms through techniques like Western blotting, immunofluorescence, and immunohistochemistry. It is particularly valuable in studies exploring mitochondrial dysfunction in conditions such as Alzheimer’s disease, Parkinson’s disease, and glioblastoma. Commercial CHCHD6 antibodies are typically validated for specificity across human and model organism samples, though batch variability and cross-reactivity with homologous proteins (e.g., CHCHD3 or CHCHD10) require careful experimental controls. Recent studies also highlight its potential as a biomarker or therapeutic target, driving demand for reliable detection tools. Overall, the CHCHD6 antibody serves as a critical reagent for unraveling mitochondrial biology and disease pathology.