ZNF598抗体;ZNF598 Antibody—艾普蒂 新品

The ZNF598 antibody is a crucial tool in studying the role of ZNF598. a zinc finger protein involved in ribosome-associated quality control (RQC) pathways. ZNF598 functions as an E3 ubiquitin ligase that recognizes stalled ribosomes during translation, marking aberrant nascent polypeptides or faulty mRNAs for degradation via ubiquitination. This process is essential for maintaining proteostasis and preventing the accumulation of toxic protein aggregates linked to neurodegenerative diseases and cancer. Researchers employ ZNF598 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interactions with ribosomes or co-factors like EDF1. Studies have highlighted ZNF598's role in resolving translational stress caused by mRNA truncations, codon repeats, or ribosome collisions, with dysregulation implicated in amyotrophic lateral sclerosis (ALS) and other disorders. The antibody's specificity and validation (e.g., knockout validation) are critical for ensuring accurate detection in diverse experimental models, including cell lines and tissue samples. Its applications span molecular biology, neurobiology, and oncology, particularly in exploring mechanisms of translational fidelity, cellular stress responses, and disease pathogenesis.