CAMK2D抗体;CAMK2D Antibody—艾普蒂

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     Western blot analysis using CAMK2D mouse mAb against  U-251MG lysate    

  
  

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     IHC-P analysis of heart tissue by CAMK2D antibody (P15496) IHC-P was performed using sections of the formalin-fixed paraffin-embedded myocardium tissue;Result: Myocardial cell are positively stained at the cytoplasm and nuclei.    

  
  

The CAMK2D antibody targets the delta isoform of calcium/calmodulin-dependent protein kinase II (CaMKIIδ), a serine/threonine kinase central to calcium-mediated signaling pathways. CaMKII is a multimeric enzyme composed of α, β, γ, and δ subunits, with CAMK2D being predominantly expressed in cardiac muscle, smooth muscle, and certain neuronal tissues. It plays a critical role in regulating cellular processes such as gene transcription, apoptosis, and ion channel activity. CAMK2D activation occurs via calcium/calmodulin binding and autophosphorylation, enabling sustained kinase activity even after calcium signals diminish.

CAMK2D dysfunction is linked to cardiovascular diseases, including cardiac hypertrophy, arrhythmias, and heart failure, as well as neurological disorders and cancer. Antibodies against CAMK2D are essential tools for studying its expression, localization, and activation status in tissues or cells. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CAMK2D's role in disease mechanisms or signaling cascades. Specificity validation (e.g., knockout controls) is crucial due to structural similarities among CaMKII isoforms. Research applications also include exploring CAMK2D as a potential therapeutic target, particularly in heart disease and oncology, where its aberrant activity may drive pathological processes.