Smc3抗体;Smc3 Antibody—艾普蒂

The SMC3 (Structural Maintenance of Chromosomes 3) antibody is a crucial tool for studying the cohesin complex, a multi-subunit protein assembly essential for chromosome organization and genomic stability. SMC3. a core component of cohesin, forms a V-shaped heterodimer with SMC1. stabilized by STAG and RAD21 subunits. This complex mediates sister chromatid cohesion during mitosis and meiosis, ensuring accurate chromosome segregation. Beyond its role in cell division, cohesin regulates DNA repair, transcription, and chromatin looping. Dysregulation of SMC3 is linked to developmental disorders (e.g., Cornelia de Lange syndrome) and cancers, particularly those with chromosomal instability. Antibodies targeting SMC3 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation. They are vital for exploring cohesin's mechanistic roles in 3D genome architecture and disease pathogenesis. Commercially available SMC3 antibodies are typically validated across human, mouse, and rat models, supporting diverse experimental applications in epigenetics and cancer biology research.