FKBP5抗体;FKBP5 Antibody—艾普蒂 新品

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     IHC-P analysis of testis tissue by FKBP5 antibody (P15297) IHC-P was performed using sections of the formalin-fixed paraffin-embedded testis tissue;Result: Cells in seminiferous ducts are positively stained at the nuclei.    

  
  

The FKBP5 antibody is a crucial tool for studying the FK506-binding protein 5 (FKBP5), a member of the immunophilin protein family involved in regulating stress responses and glucocorticoid receptor (GR) signaling. FKBP5 acts as a co-chaperone for heat shock protein 90 (Hsp90), modulating GR sensitivity by forming a negative feedback loop. Elevated FKBP5 expression reduces GR ligand affinity, impairing stress hormone regulation and contributing to hypothalamic-pituitary-adrenal (HPA) axis dysregulation linked to psychiatric disorders like depression, PTSD, and anxiety.

FKBP5 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in tissues or cell lines. These antibodies help explore FKBP5’s role in cellular stress adaptation, apoptosis, and immune responses. Researchers also utilize them to investigate genetic variants (e.g., rs1360780) associated with altered FKBP5 expression and disease susceptibility. Commercial FKBP5 antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions), with validation via knockout controls or siRNA knockdown. Their applications span neuroscience, endocrinology, and pharmacology, aiding drug development targeting FKBP5-GR interactions for stress-related disorders.