PSMD1抗体;PSMD1 Antibody—艾普蒂 新品

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     Western blot analysis using PSMD1 mouse mAb against  A-431 lysate    

  
  

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     Lane 1: Hep G2 lysate ;  Lane 2: PSMD1 immunoprecipitated from Hep G2 lysate by P15211 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15211 can immunoprecipitate PSMD1;    

  
  

The PSMD1 antibody is a research tool designed to detect and study the 26S proteasome non-ATPase regulatory subunit 1 (PSMD1), a key component of the ubiquitin-proteasome system (UPS). PSMD1. also known as Rpn2. is part of the 19S regulatory particle of the 26S proteasome, which is responsible for recognizing and deubiquitinating polyubiquitinated proteins before their degradation by the proteasome’s catalytic core. This subunit plays a critical role in maintaining protein homeostasis, regulating cellular processes such as cell cycle progression, DNA repair, and apoptosis. Dysregulation of PSMD1 has been implicated in various diseases, including cancers and neurodegenerative disorders, making it a focus of therapeutic research.

PSMD1 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate proteasome structure, function, and localization. They help researchers assess PSMD1 expression levels in different tissues or under specific conditions, such as stress or disease states. Many studies utilize these antibodies to explore the correlation between PSMD1 overexpression and cancer progression, particularly in drug-resistant tumors. Both monoclonal and polyclonal PSMD1 antibodies are available, with validation often performed using knockout cell lines or siRNA-mediated silencing to confirm specificity. Recent advances in proteasome-targeted therapies, including inhibitors and immunomodulators, have further driven the demand for reliable PSMD1 antibodies in mechanistic and drug discovery studies.