GIMAP8抗体;GIMAP8 Antibody—艾普蒂 新品

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     IHC-P analysis of tonsil tissue by GIMAP8 antibody (P15204) IHC-P was performed using sections of the formalin-fixed paraffin-embedded tonsil tissue;Result: Non-germinal center cells are positively stained at the cytoplasm.    

  
  

GIMAP8 (GTPase of the immunity-associated protein 8) is a member of the GIMAP family, a group of evolutionary conserved proteins characterized by a GTP-binding domain and roles in immune system regulation. These proteins are predominantly expressed in lymphocytes and are implicated in cell survival, apoptosis, and autophagy. GIMAP8. specifically, is thought to function in maintaining immune homeostasis, potentially through interactions with intracellular organelles or modulation of signaling pathways. Studies suggest its involvement in T-cell development and survival, though its precise mechanisms remain less defined compared to other family members like GIMAP5 or GIMAP7.

Antibodies targeting GIMAP8 are critical tools for elucidating its biological functions. They enable detection and localization of the protein in tissues or cultured cells via techniques such as Western blotting, immunohistochemistry, or flow cytometry. Such antibodies have been employed in research exploring immune disorders, including autoimmune diseases and lymphopenia, as well as cancer immunology, where dysregulated lymphocyte survival pathways may contribute to pathogenesis. Commercial GIMAP8 antibodies are typically raised against specific epitopes, often as monoclonal or polyclonal versions validated for cross-reactivity and specificity. Recent investigations highlight GIMAP8's potential role in metabolic stress responses, linking it to broader cellular adaptation mechanisms, which underscores the growing interest in developing reliable antibodies for both basic and translational studies.