MYO6抗体;MYO6 Antibody—艾普蒂

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     Western blot analysis using MYO6 mouse mAb against  HT-29 lysate    

  
  

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     Lane 1: HT-29 lysate ;  Lane 2: MYO6 immunoprecipitated from HT-29 lysate by P15183 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15183 can immunoprecipitate MYO6;    

  
  

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     IHC-P analysis of kidney tissue by MYO6 antibody (P15183) IHC-P was performed using sections of the formalin-fixed paraffin-embedded kidney tissue;Result: Cells in tubules are positively stained at the cytoplasm and membrane.    

  
  

Myosin VI (MYO6) is a unique member of the myosin superfamily, a group of motor proteins critical for actin-based cellular processes. Unlike most myosins, which move toward the plus end of actin filaments, MYO6 exhibits minus-end-directed movement, enabling specialized roles in intracellular transport, endocytosis, and maintenance of cell polarity. It plays essential functions in diverse tissues, including inner ear hair cells, where it stabilizes stereocilia structures and facilitates auditory signal transduction. Mutations in the MYO6 gene are linked to hereditary hearing loss (DFNA22) and other disorders, driving interest in its molecular mechanisms.

MYO6 antibodies are vital tools for studying the protein's expression, localization, and interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MYO6's role in cellular dynamics, disease models, and developmental processes. High-quality antibodies are validated for specificity, often using knockout controls, to ensure accurate detection in complex biological samples.

Research involving MYO6 antibodies has expanded into cancer and neurodegenerative diseases, as MYO6 dysregulation is implicated in tumor invasiveness, synaptic dysfunction, and vesicle trafficking defects. These antibodies also aid in exploring MYO6's potential as a therapeutic target, particularly in hearing restoration strategies. Overall, MYO6 antibodies serve as indispensable reagents for unraveling the protein's multifaceted contributions to cellular physiology and pathology.