CDHR5抗体;CDHR5 Antibody—艾普蒂 新品

+ +

•  

   

     IHC-P analysis of small intestine tissue by CDHR5 antibody (P15181) IHC-P was performed using sections of the formalin-fixed paraffin-embedded small intestine tissue;Result: Microvilli are positively stained.    

  
  

**Background of CDHR5 Antibody**

CDHR5 (Cadherin-Related Family Member 5), also known as protocadherin-24. is a calcium-dependent cell adhesion protein belonging to the cadherin superfamily. It is primarily expressed in epithelial tissues, particularly in the kidney, intestine, and lung, where it plays a role in maintaining cell-cell adhesion and tissue integrity. Structurally, CDHR5 contains multiple extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail, though its exact signaling mechanisms remain less characterized compared to classical cadherins like E-cadherin.

CDHR5 antibodies are tools developed to detect and study the expression, localization, and function of this protein. Research has linked CDHR5 to epithelial polarization, barrier formation, and potential roles in disease contexts. For instance, altered CDHR5 expression has been observed in certain cancers, suggesting its involvement in tumor progression or metastasis. Additionally, CDHR5 is studied in renal and gastrointestinal pathologies, where epithelial dysfunction is a hallmark.

These antibodies are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to explore CDHR5's biological significance. Their development has facilitated insights into epithelial cell biology and provided a foundation for investigating CDHR5 as a diagnostic or therapeutic target in diseases involving epithelial integrity loss. Further studies are needed to fully elucidate its molecular interactions and clinical relevance.