NFX1抗体;NFX1 Antibody—艾普蒂 新品

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     Western blot analysis using NFX1 mouse mAb against  SK-OV-3 lysate    

  
  

The NFX1 (Nuclear Transcription Factor, X-box Binding 1) protein is a transcription factor involved in regulating gene expression, particularly through interactions with the X-box DNA motif. It exists in two major isoforms, NFX1-123 and NFX1-91. generated via alternative splicing. NFX1-123 contains tandem zinc finger domains critical for its role in transcriptional repression, while NFX1-91 lacks these domains and may function as a dominant-negative regulator. NFX1 is implicated in immune response modulation, cellular differentiation, and viral-host interactions, including pathways linked to human papillomavirus (HPV) infections and cancer progression.

Antibodies targeting NFX1 are essential tools for studying its expression, localization, and molecular interactions. These antibodies, often developed in rabbit or mouse hosts, enable detection via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Specificity is validated using knockout cell lines or recombinant protein controls. Research applications include investigating NFX1's role in telomerase regulation, immune signaling (e.g., NF-κB pathways), and its dual function as a tumor suppressor or oncogene depending on cellular context. Recent studies also explore its interplay with viral oncoproteins, offering insights into therapeutic targets for HPV-associated malignancies.